Development of a coarse-grained model of SARS-CoV-2 virion

A team of scientists of the University of Chicago and the University of California San Diego has developed a coarse-grained (CG) model of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virion. The model can be used as a valuable resource to perform multiscale simulations of the SARS-CoV-2 virion. The study is currently available on the bioRxiv* preprint server.

SARS-CoV-2, the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, is a positive-sense single-stranded RNA virus with a genome size of 30 kb. To obtain a detailed overview of SARS-CoV-2 viral proteins and their functions, many structural biology studies have been performed using cryo-electron microscopy and x-ray crystallographic techniques. Simultaneously, many computational biology studies have also been done to predict unresolved genome regions using multiple protein folding algorithms. However, given the difficulty in simulating biomolecules at atomic resolutions, all-atom molecular dynamic simulation of various viral processes, such as virion

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A TLR2 agonist reduces SARS-CoV-2 in upper respiratory tract of ferret model

It is essential to potentiate the human respiratory system’s antiviral immune defenses to reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral shedding in the upper respiratory tract (URT) and control the viral transmission. A prophylactic intranasal administration of the TLR2/6 agonist INNA-051 exhibits viral reduction – this offers a promising approach for possible prevention and management of SARS-CoV-2 infection, particularly useful to individuals at elevated risk of community transmission.

The respiratory virus, SARS-CoV-2, causing the current COVID-19 disease pandemic, initially infects the upper respiratory tract (URT). Infected people may be symptomatic, pre- or asymptomatic, spreading the virus nonetheless. Asymptomatic individuals shed the virus and transmit the disease longer than those with symptoms. It is essential to restrict the initial replication of the virus in URT to prevent the progression of the disease. In a recent bioRxiv* preprint paper, Professor Miles W. Carroll et al. study an agonist for

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