Passage Bio’s PBGM01 shows encouraging pre-clinical benefits in murine model of GM1 gangliosidosis (NASDAQ:PASG)

Passage Bio (NASDAQ:PASG) announces publication of data in a murine model of GM1 gangliosidosis (GM1) demonstrating that a single intracerebroventricular injection of an optimized adeno-associated virus (PBGM01) into the cerebral spinal fluid (CSF) resulted in significant expression of Beta-galactosidase (β-gal) in the brain and peripheral tissues, and demonstrated dose-related reductions in neuronal lysosomal storage lesions, neurological impairment and improvement in survival.

GM1 is a rare and often life-threatening lysosomal storage disease caused by mutations in the GLB1 gene, which encodes lysosomal acid β-gal.

The mice received the single administration at age one month and were evaluated over 300 days. β-gal activity was increased significantly in the CSF and serum of the vector-treated mice compared to vehicle control-treated mice.

Considerable improvements in gait assessments and preservation of neurological function were observed throughout the study period.

There were significant decreases in lysosomal storage lesions of vector-treated animals, and by day 300, all

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Piaggio India today announced festive season discounts and benefits on its Vespa and Aprilia range of scooters. The offers will be valid until the 16th of November 2020. During this time period, customers will be able to avail benefits of up to Rs 10,000 on purchase of any Vespa and Aprilia scooter variants, including the BS6 Vespa facelift and BS6 Aprilia range across dealerships in the country. The festive offer entails insurance benefit of up to Rs 7,000, complementary accessories worth up to Rs 4,000 and an e-commerce booking benefit of Rs 2,000. Furthermore, this Dusshera and Diwali, customers can avail of the first year of free service and five years of warranty which includes free roadside assistance for two years.

Vespa VXL and SXL range get Monocoque full steel body, three-coat body colours, combined braking system (CBS) with twin pot calliper disk brakes.

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Medterra CBD Oil Review – Read Benefits Of Medterra CBD Oil Coupon And Ingredients!

Press release content from TS Newswire. The AP news staff was not involved in its creation.

New York, NY ( TS Newswire ) — 25 Sep 2020

Medterra CBD Oil- Stress is the cause of several health problems and in this modern age, half of the world is unable to cope up with daily stress. It can lead to several problems like sleeplessness and other serious health problems. We have a product that can handle such issues and it will also heal your chronic pains. Medterra CBD Oil is a pure and natural CBD product that contains genuine hemp oil and it has been certified by the authorities as well. It is a natural solution for problems like depression, anxiety disorders, and chronic pains. You do not have to worry about this product because it will not make you high and THC has been removed from

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Fab CBD Oil Reviews – Read Benefits Of Fab CBD Oil Coupon Code And Ingredients

Press release content from TS Newswire. The AP news staff was not involved in its creation.

New York, NY ( TS Newswire ) — 25 Sep 2020

What is the use of Fab CBD Oil in daily life?

Chronic health problems of the people in recent years are found to be increasing. But the main cause behind these problems is stress and depression. Everything that we do today takes a lot of courage and strength. Every decision we take today depends on the future. So this is where stress begins. Taking stress is not a bad sign but over stress is something that can destroy human health. So it is advised that stress should be taken in limit or stay calm. (LIMITED STOCK) Click Here to Order This Best CBD OIL For The Lowest Price Online

Henceforth, to cure this problem Fab CBD Oil is been

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Benefits Of Wearing Navaratna (9 Stones) Jewelry And How To Put on It The Right Approach

Lengthy earlier than the invention of the American Dollar, the Indian Rupee, or the British Pound, another type of forex was utilized by individuals world wide. Widespread metals embody silver, gold, platinum, base metals. The unpredictable availability of, as an illustration, diamond, gold, and sterling silver jewelry is a truth of life for wholesale jewelry distributors. Although the pieces may look the same, one piece of jewelry could cause discoloration while one other may not.

Archeologists have discovered examples of scarab beads and artifacts produced from clay, soapstone, inexperienced basalt, glass, bone, treasured metals, wooden, semi-valuable gemstones and plenty of different varieties of stone. If you wish to actually highlight your earrings, avoid wearing a necklace and select longer, hanging styles of earrings or studs which can be dazzling gems.

If the earrings gift is pricey, hmm, one thing attention-grabbing between them. At present, scarab jewelry is still produced from … Read More

Benefits Of Carrying Navaratna (9 Stones) Jewelry And How To Put on It The Right Approach

Surprise what more so as to add to your jewelry assortment in your jewelry field? Opposite to what most people consider, jewelries shouldn’t have to be diamond jewelry, gold jewelry or valuable heirlooms like vintage jewelry, estate jewelry, Hawaiian jewelry or Italian jewelry in order to be thought of tremendous pieces. Even some costume jewelry is sort of stunning and far less expensive than “the true factor.” The necessary factor about jewelry is ensuring it fits the wearer’s style.

Unlike with silver or gold, chrome steel jewelry will not be bought for both fashion and investment functions. The necklaces are beautiful. You have got the everyday yellow gold, a inexperienced gold, the ever well-liked white gold which is at present making a little bit of a comeback, and the sought after ‘Rose gold,’ trendy in Victorian and Vintage Jewelry.

It takes a set of tables to work out the precise … Read More

6 Benefits Of A Beauty Salon

Heart is stuffed with happiness when it sees or feels one thing stunning. Beauty salon provides often embrace all the mandatory topical creams, gels, and different products used for styling and taking care of our hair, skin, nails, toes, hand, and hair elimination. This substance contains the useful enzymes and bacteria and is the place all the skincare benefits of apple cider vinegar lie.There are lots of manufacturers to select from, so you need to discover one which’s simply available in your space.

To look deep into a woman, a lot might be learned about her true beauty. Juice improves a woman’s determine as well as her skin, hair, and eyesight. If you are one of many many who feel that character-pushed excessive drama (generally pertaining to melodrama) is one thing sadly missing in modern fiction, the The Ugly Face of Beauty is for you.

I simply know beauty when … Read More