Researchers create p16-Cre ERT2 -tdTomato mouse model to characterize in vivo senescent cells

Cell senescence is a state of permanent cell cycle arrest that was initially defined for cells grown in cell culture. It plays a key role in age-associated organ dysfunction and age-related diseases such as cancer, but the in vivo pathogenesis is largely unclear.

A research team led by Professor Makoto Nakanishi of the Institute of Medical Science, the University of Tokyo, generated a p16-Cre ERT2 -tdTomato mouse model to characterize in vivo p16 high cells at the single-cell level.

They found tdTomato-positive p16 high cells detectable in all organs, which were enriched with age. They also found that these cells failed to proliferate and had half-lives ranging from 2.6 to 4.2 months, depending on the tissue examined.

Single-cell transcriptomics in the liver and kidneys revealed that p16 high cells were present in various cell types, though most dominant in hepatic endothelium and

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Microsoft announces new keyboard, mouse and other accessories

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Accused Gangster Charged With Ambush Shooting of L.A. Deputies

After a three-week manhunt, a Los Angeles man was arrested and charged Wednesday with attempting to murder two sheriff’s deputies who were ambushed as they sat in their car.Deonte Lee Murray, 36, is facing two counts of attempted murder of a peace officer and possession of a firearm for allegedly walking up to the squad car parked outside a Metro station on Sept. 12 and opening fire, the Los Angeles County District Attorney’s Office said Wednesday.“They became victims of a violent crime for one reason: They wear a badge,” L.A. County District Attorney Jackie Lacey said in a press conference.‘Cowardly’: Video Shows Gunman Ambushing Two L.A. Deputies in Patrol CarMurray, who faces a maximum sentence of life in prison, was recently charged with attempted murder for a carjacking in Compton two weeks before the shooting. He allegedly used

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