Memphis vs. SMU odds, line: 2020 college football picks, Week 5 predictions from proven computer model

Get ready for an American Athletic battle as the SMU Mustangs and the Memphis Tigers will face off at 3:30 p.m. ET on Saturday at Gerald J. Ford Stadium. SMU is 3-0 overall and 1-0 at home, while Memphis is 1-0 overall and playing its first road game of the season. It’s the 13th time the two programs have gone head-to-head and Memphis has ridden a six-game winning streak to a 9-3 record in the series. 

Memphis is 5-0-1 against the spread during that winning streak, but SMU did push last season as six-point underdogs in a 54-48 loss. The Tigers are favored by 2.5-points in the latest Memphis vs. SMU odds from William Hill, and the over-under is set at 74.5. Before entering any SMU vs. Memphis picks, you’ll want to see the college football predictions from the model at SportsLine.

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